abstract |
Chemical formula (Ia) Compound. Wherein R 1 , R 2 , R 3 , R 4a , R 4b , R 5 and R 6 are defined herein, and other indene derivatives are disclosed herein. Also disclosed are pharmaceutical compositions comprising the compounds and methods of using the compounds. A compound of the invention disclosed herein or a pharmaceutical composition comprising one or more of the compounds and a pharmaceutically acceptable carrier, diluent or excipient treats or prevents a proliferative disorder in a patient Can be used in the method. The method includes the step of administering an amount of a compound or composition of the invention to a patient in need thereof, the amount being effective to treat or prevent a proliferative disorder in the patient. |