| abstract |
The present invention provides fusion polypeptides that can bind interleukin-1 (IL-1) to form a non-functional complex. Nucleic acids encoding the fusion polypeptides and methods for making and using the fusion polypeptides are also provided. The nucleic acid is an isolated nucleic acid molecule comprising a sequence selected from the group consisting of SEQ ID NOs: 1, 3, 5, 7, 9, 11, 13, 15, 17, 19, 21, and 23, wherein IL An isolated nucleic acid molecule that encodes a fusion polypeptide that forms a multimer that can bind -1 to form a non-functional complex. |