| abstract |
The present invention describes vitamin receptor binding drug delivery conjugates and methods for their preparation. The drug delivery conjugate consists of a vitamin receptor binding component, a divalent linker (L), and a drug. The vitamin receptor binding component is a vitamin or a vitamin receptor binding analog or derivative thereof, and the drug includes the analog or derivative thereof. The vitamin receptor binding component is covalently bonded to the bivalent linker, the drug or analog or derivative thereof is covalently bonded to the bivalent linker, and the bivalent linker (L) is one or more spacer linkers, release linkers, And a heteroatom linker. Also described are methods and pharmaceutical compositions for removing pathogenic cell populations using the drug delivery conjugates. |