| abstract |
The present invention relates to polynucleotide sequences corresponding to tor-1, tor-2, ooc-5, DYT1, and DYT2 genes and portions thereof encoding polypeptide sequences having various degrees of torsin activity and portions thereof. And methods for screening polynucleotides encoding polypeptide sequences encoding polypeptides having varying degrees of TOR-1, TOR2, OOC-5, TOR-A, and TOR-B activity, and It relates to a method of amplification. Furthermore, the present invention provides a method for reducing protein aggregation, a method for treating a disease caused by protein aggregation, a method for screening a product that may reduce protein aggregation, a therapeutic drug candidate for a disease caused by protein aggregation. The present invention relates to a screening method, a medicament, a therapeutic agent, and a kit containing a polynucleotide corresponding to tor-1, tor-2, ooc-5, DYT1, and DYT2 gene and / or a polypeptide having torsin activity. |