| abstract |
Disclosed are compounds, compositions, and pharmaceutical compositions comprising oligonucleotides capable of interfering with protein aggregates that are characteristic of diseases of protein assembly. Similarly, in vitro and in vivo methods for identifying such oligonucleotides and methods for treating such diseases by administering such compositions are disclosed. More specifically, a method for identifying an oligonucleotide species effective to prevent aggregation of protein aggregates in a cell from a plurality of oligonucleotide species having different sequences and / or compositions Each of a plurality of oligonucleotide species of sequence and / or composition is introduced separately into cells where the protein aggregates are aggregated or where such aggregation can occur to prevent, reduce or prevent the aggregation Provided by the present invention is a method comprising identifying one or more of a plurality of oligonucleotide species effective in doing so. |