| abstract |
The object of the present invention is to provide novel mono-acylated o-phenylenediamine derivatives of the formula (A) and their pharmaceutically acceptable salts, processes for preparing these compounds, pharmaceutical compositions containing such compounds And their use in the manufacture of drugs to treat diseases such as cancer: Where Ar is thiophene-2,5-diyl, pyridine-2,5-diyl, pyridine-5,2-diyl, pyridine-2,6-diyl, pyridine-2,4-diyl or 1,4-phenylene R 1 and R 2 are independently of each other hydrogen, C 1-12 alkyl, C 2-12 alkenyl, C 2-12 alkynyl, C 3-12 cycloalkyl, and said alkyl, alkenyl, alkynyl and cyclo Alkyl groups are hydroxy, halogen, C 3-12 cycloalkyl, alkoxy, alkylsulfanyl, acyloxy, alkoxycarbonyl, acyl, C 1-6 alkyl-NH-C (O)-, C 1-6 alkyl-C (O) NH-, or -NR 3 R 4 may be substituted one to many times, or R 1 is hydrogen, and R 2 is hydroxyl, alkoxy, C 2-12 alkenyloxy or phenoxy, The phenoxy group may be methyl, methoxy, halogen, nitro, Bruno, trifluoromethyl, it may be substituted by ethenyl or -C (O) -O-CH 3 , provided that when R 2 is hydroxy, Ar is not a thiophene-2,5-diyl, and R 3 And R 4 independently of one another are hydrogen or C 1-6 alkyl, or R 3 and R 4 together with the nitrogen atom to which they are attached form a ring, said ring being monosubstituted with oxo And the ring can contain further heteroatoms. [Chemical 1] |