| abstract |
PROBLEM TO BE SOLVED: To use a carboxylic acid derivative which can be easily obtained or manufactured as a starting material without using a corrosive or bad odor reagent as a reagent used in the reaction, and completely retaining the three-dimensional form of the carboxylic acid derivative as a raw material Difluoroacetic acid is obtained in high yield. A process for producing a difluoro derivative represented by formula (8) using a carboxylic acid derivative represented by formula (1) as a starting material and passing through a substituted difluoroacetic acid represented by formula (5). R 1 is, for example, hydrogen; R 2 is, for example, a divalent organic group; R 3 is 1,4-cyclohexylene or a group represented by formula (12); R 4 is, for example, hydrogen; X 1 is —O—, —COO— or —CONH—; Y 1 is, for example, hydrogen; R 6 and R 7 are, for example, a monovalent organic group; and R 8 is a divalent organic group. . In the formula (12), ring A 1 is, for example, it is a 1,4-cyclohexylene; o is an integer of 0. [Selection figure] None |