| abstract |
PROBLEM TO BE SOLVED: To provide a compound having excellent oral absorption and safe melanin-concentrating hormone receptor antagonist activity. Agents for preventing and treating obesity. SOLUTION: General formula (I): Wherein Ar 1 is (substituted) aryldiyl and the like; Ar 2 is (substituted) aryl and the like; R 1 and R 2 independently contain C 1-6 alkyl, or an adjacent nitrogen atom and are 5- or 6-membered non- An aromatic heterocyclic ring may be formed; R 3 is a halogen atom or the like; X 1 is a formula: —C (═Z 1 ) N (R 4 ) — or the like (wherein R 4 is a hydrogen atom or the like; Z 1 Or Ar 1 and X 1 may be substituted together; X 2 is C 1-6 alkylene; X 3 is C 1-6 alkylene, etc .; or X 3 and R 2 are May form a pyrrolidine ring or a piperidine ring containing adjacent nitrogen atoms together; M is an oxygen atom or the like; m is 0 or 1; n is 0, 1, 2 or 3), a salt thereof Or a melanin-concentrating hormone receptor antagonistic pharmaceutical composition comprising a solvate as an active ingredient. [Selection figure] None |