| abstract |
The present invention relates to compositions and methods for treating neoplasms in mammals, particularly humans. More particularly, the present invention provides a method for the prevention, treatment or delay of mammalian neoplasms using ErbB-3 protein, nucleic acid encoding ErbB-3 protein, or a functional fragment thereof. The present invention also provides an isolated nucleic acid encoding an extracellular domain of ErbB-3 protein or a functional fragment thereof or a substantially purified extracellular domain of ErbB-3 protein or a functional fragment thereof and ErbB-3 protein. Antibodies that bind to an epitope in the extracellular domain or functional fragment thereof are provided. The present invention further provides a pharmaceutical composition and / or vaccine comprising an extracellular domain of ErbB-3 protein or a functional fragment or encoding nucleic acid thereof and an antibody that binds to such extracellular domain or a functional fragment thereof. provide. |