http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2005532256-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-505 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-2803 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 |
| filingDate | 2002-11-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2005-10-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2005532256-A |
| titleOfInvention | Modulation of LIR function to treat rheumatoid arthritis |
| abstract | The present invention relates to a method of treating rheumatoid arthritis (RA) by administering one or more agents that specifically target LIR-2, LIR-3 and LIR-7. The results disclosed herein indicate that these three LIRs may be involved in controlling the activation of leukocytes that infiltrate synovial tissue. Thus, inflammation in RA patient joints may reduce or eliminate the activation of monocytes or macrophages present in inflamed joints or reduce their recruitment to sites of inflammation. And / or can be improved by administering an agent that modulates the expression or function of LIR-3 and / or LIR-7. This can be done by modulating LIR-7 that transmits a stimulatory signal and / or by adjusting LIR-2 and / or LIR-3 that exerts an inhibitory effect when induced, or of these LIRs It can be achieved by adjusting two or all three of them simultaneously. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2010101192-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-5637981-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2015537009-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2013517331-A |
| priorityDate | 2001-11-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 259.