| abstract |
A novel compound of general formula (1) which is an inhibitor of one or more post-proline cleavage proteases such as dipeptidyl peptidase IV. R 1 is H or CN, X 1 is O, S, CH 2 , CHF, CF 2 , CH (CH 3 ), C (CH 3 ) 2 or CH (CN), b is 1 Or 2. G 1 is H or a group of formula —CH 2 —X 2 — (CH 2 ) a —G 3 , and G 2 is H or is of formula —CH 2 — (CH 2 9 a — A group of G 3 provided that one of G 1 and G 2 is H and the other is not H. X 2 is O, S or CH 2 and a is 0, 1 or 2, provided that when a is 1, X 2 is CH 2. G 3 is one group of general formulas (2) to (4); The variables have the meanings given in the specification The compounds are particularly useful in the treatment of type 2 diabetes and impaired glucose tolerance. [Chemical 1] |