| abstract |
The present invention relates to the production of antibodies that bind to specific modifications at the amino terminus of histone H3 and H2A peptides. More preferably, the present invention is directed to the generation of a group of antibodies that recognize various post-translational modifications of the histone modification cassette SRGRGK (SEQ ID NO: 1), wherein the modification comprises phosphorylated serine, methylated arginine and Selected from the group consisting of acetylated lysine. Compositions containing these antibodies are used as diagnostic and screening tools. |