| abstract |
The present invention is directed to compositions and methods for the detection of malignant conditions and relates to the discovery of soluble and cell surface forms of HE4a polypeptide, eg, HE4a overexpressed in ovarian cancer. In particular, the present invention provides nucleic acid sequences encoding HE4a and the reaction of antibodies specific for HE4a polypeptide with molecules that are naturally present in soluble and / or cell surface form in samples from such subjects. Also provided are methods of screening for the presence of malignant symptoms in a subject by detecting sex and by hybridization screening using the HE4a nucleotide sequence and other related advantages. |