| abstract |
[Problem] (a) Causes activation of NF-κB, which is a cause of accelerating transcription of genes related to immunity, inflammatory reaction, cell proliferation control, and apoptosis; (b) inhibition of intracellular signal transduction of insulin; Disclosed is an IκB kinase inhibitor that inhibits IκB kinase having properties such as causing a decrease in function (phosphorylation) of IRS-1, which is a cause of inhibition of glucose uptake. An active ingredient contains at least one selected from an extract obtained from a fruit or peel of mangosteen (Garcinia mangostana L.) with a water-containing organic solvent or an organic solvent, α-mangostin and γ-mangostin. IκB kinase inhibitors and compositions containing them. [Selection figure] None |