| abstract |
The present invention provides a polymorphic indole compound and a method for controlling the crystal form. 1- (N, N-dimethylsulfamoyl) -3- [3-bromo-6-fluoro-2-methylindol-1-yl] sulfonyl-1,2,4-triazole And low-melting-point crystals and methods for producing them, in the crystallization stage by cooling or concentrating the solution, by the method of solid phase transition by pulverization or the like applying pressure and / or heat, and the rate of cooling and / or concentration A method for producing a high melting point crystal or a low melting point crystal characterized by controlling the crystal form by changing the degree of supersaturation of the solution, and a method for producing a high melting point crystal by a crystallization method by mixing the solution with a poor solvent. [Selection figure] None |