| abstract |
The present invention relates to polynucleotides encoding immunogenic HIV polypeptides. The use of polypeptides in applications including immunization, production of packaged cell lines, and production of HIV polypeptides is also described. Polynucleotides encoding antigenic HIV polypeptides are described, as well as the use of these polynucleotides and polypeptide products derived therefrom, including the formulation of immunogenic compositions and their use. The present invention also discloses synthetic polynucleotides encoding two or more immunogenic HIV polypeptides, wherein at least two of the polypeptides are from different HIV subtypes. |