| abstract |
According to the present invention, a one-step method for producing a cytotoxic conjugate of a maytansinoid and a cell binding agent is disclosed. A maytansinoid comprising a disulfide linker with a reactive moiety is linked to a cell binding agent such as an antibody without prior modification of the cell binding agent. This conjugate is useful as a therapeutic agent for cytotoxicity specifically delivered to target cells. |