| abstract |
A bioadhesive tablet in which the active ingredient is protected from moisture or the surrounding environment. The active ingredient is protected from metabolism and from degradation by moisture, enzymes, pH action and exhibits bioavailability at a controlled rate. The active ingredient is protected from moisture during manufacture and, more importantly, is protected from moisture until after the patient uses the tablet at a moderately controlled rate. This gradual hydration protects the active ingredient for a long time after administration. This progressive hydration also achieves a controlled sustained release. This is because only the portion of the active ingredient that is the hydrated (aqueous) fraction of the tablet is utilized for absorption (bioavailability). |