| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_78762477d897b38c0e330d115c9f2f3a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9019c0ce5cb7b82c85e121f6cac86dce |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7088 |
| filingDate |
2003-02-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_125c9cfe8966ea4e16cc5590191a9bf6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1a879e6adc55e8ef6891f8c430565475
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_67a5dd283b89193bb800adcb66c862f6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e18f21637055279d15bb477e1f9e8154
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_46db956098c8003872dd556a0cd97c96
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a6a4a0217306c27c286f88ebad117560 |
| publicationDate |
2004-09-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
JP-2004261024-A |
| titleOfInvention |
Gene therapy using peptide-modified polysaccharide |
| abstract |
An object of the present invention is to provide a complex of an oligonucleotide effective for applying an antisense drug to various diseases involving a gene with a new type of carrier which is safe and has a high transfection effect, and provides the same as a gene therapy agent. It is in. A novel carrier can be obtained by introducing a peptide chain having an affinity for a cell membrane and having a high transfection effect into a polysaccharide as a modifying group. When this is conjugated with an antisense oligonucleotide which is substantially complementary to the gene sequence of the disease of interest as a therapeutic agent, a high suppression rate of the disease and low toxicity can be obtained. . [Selection diagram] Fig. 4 |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-4712333-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3822292-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2006069913-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2016535058-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10793603-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2009078470-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10738304-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8137964-B2 |
| priorityDate |
2003-02-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |