| abstract |
An oral antithrombotic and thrombolytic agent having excellent t-PA activating activity and PAI-1 inhibitory activity. SOLUTION: Expression (1) Embedded image (Wherein a is a substituted phenyl group, a substituted naphthyl group, etc., b is a hydroxyl group, a benzyloxy group, etc.) pyrimidine derivatives have excellent t-PA activating activity and PAI-1 inhibitory activity, and can be administered orally. It can be used as a thrombolytic or thrombolytic agent. [Selection diagram] None |