| abstract |
The present invention discloses a compound capable of modulating the activity of β-amino-β-carboxymuconate-ε-semialdehyde decarboxylase (ACMSD), which can be used to prevent and/or treat NAD + biosynthesis defects Diseases or conditions such as metabolic disorders, neurodegenerative diseases, chronic inflammatory diseases, renal disease and aging-related disorders. The present application also discloses pharmaceutical compositions comprising the compounds and the use of the compounds as medicaments. |