http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2003500415-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-02 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C40B40-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-103 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C40B50-06 |
| filingDate | 2000-05-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2003-01-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2003500415-A |
| titleOfInvention | Peptide synthesis method using ion exchange resin as a scavenger to minimize isolation processing |
| abstract | (57) Abstract: A method for producing a polypeptide having a predetermined number and sequence of amino acid residues, wherein a first substrate amino acid or peptide fragment is replaced with a stoichiometric excess of a second reactant amino acid or peptide fragment. A second step of contacting the reaction solution obtained in the first step with an insoluble scavenger to sequester the excess of the second reactant amino acid or peptide fragment; A third step of removing the sequestered excess of the second reactant amino acid or peptide fragment from the solution; and reacting the reaction solution to remove protecting groups from the N- or C-terminus of the condensation product of the first step. A fourth step of reacting and, if necessary, a fifth step of repeating the first to fourth steps. According to the method of the present invention, a peptide can be mass-produced in a solution, and there is no restriction on one end of a solid phase method, which has "cleanliness" of the solid phase method. Similarly, full automation is possible. The most important advantage, however, is that the process of the present invention does not require frequent isolation of intermediates during long synthetic steps, nor does it necessarily completely eliminate any by-products from the reaction mixture prior to subsequent processing steps. It is not necessary to do it. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8716439-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-WO2016140232-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2016140232-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11098078-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2007099656-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9346850-B2 |
| priorityDate | 1999-05-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 54.