| abstract |
(57) [Problem] To provide a refreshing composition or a composition for applying mucous membranes (such as eye drops) that can enhance and maintain a refreshing feeling in a composition containing a refreshing component. SOLUTION: When a compound represented by the following formula (1) (such as caffeine) or a salt thereof is combined with a cooling component (menthol, camphor, borneol, etc.), a compound represented by the following formula (1) or The salt can maintain the refreshing feeling of the cooling component. Furthermore, the compound (1) can also maintain and maintain the cooling sensation due to the cooling component. The ratio of the compound (1) or a salt thereof is as follows: In terms of a free compound, the amount is about 0.1 to 1000 parts by weight based on 1 part by weight of the cooling component. The refreshing composition can be used as a composition for applying to mucous membranes (solutions such as eye drops, eyewashes, nasal drops, agents for contact lenses, and ointments such as eye ointments). Embedded image (Wherein R 1 , R 2 and R 3 represent a hydrogen atom or an optionally substituted alkyl group) |