| abstract |
PROBLEM TO BE SOLVED: To provide a novel carboxylic acid derivative having Cdc25 phosphatase inhibitory activity and a medicament containing the derivative. SOLUTION: The carboxylic acid derivative of the present invention has a general formula (I): [In the formula, R 1 represents a hydrogen atom, a cycloalkyl group, or the like. W represents CH or N, X is an oxygen atom, -OC Represents an H 2 — group or an —NR 4 — group (R 4 represents a hydrogen atom, a lower alkyl group, or the like). Y represents a 1,4-piperazinyl group, an NHCHR 5 CONH— group (R 5 represents a hydrogen atom or a lower alkyl group which may have a functional group) or N H represents a group, and Z represents a carbonyl group or a sulfonyl group. R 2 represents an alkyl group, a phenyl group, or the like; 3 represents a hydrogen atom or a lower alkyl group. j is 0 Or 1, k represents 0 or 1, l represents an integer of 0 to 6, m represents an integer of 1 to 10, and n represents 0 or 1. Or a pharmaceutically acceptable salt thereof. |