| abstract |
PROBLEM TO BE SOLVED: To provide a technique for avoiding a decrease in the absorbability of a drug due to a drug metabolizing enzyme or a drug transporter present in the digestive tract and improving the bioavailability of the drug. SOLUTION: An agent for improving oral absorption of a drug containing a lignan compound having a methylenedioxyphenyl group as an active ingredient, the lignan compound, a drug serving as a substrate for the drug metabolizing enzyme CYP3A, and a drug metabolizing enzyme CYP2C A pharmaceutical composition comprising a drug serving as a substrate for the drug or a drug serving as a substrate for the drug transporter P-glycoprotein. |