| abstract |
(57) [Summary] The present invention provides a method for sustaining the transfer of drug molecules from microspheres, nanospheres and films, which is transmitted in the form of microspheres, nanospheres and films, and comprises highly efficiently encapsulated drug molecules and biodegradable polymers. And a method for producing the same. To meet the above objectives, the biodegradable polymer is combined with the delivered drug molecule and formulated into microparticles, nanoparticles or films for each delivery. In this case, the release rate of the molecule is mainly proportional to the degradation rate of the biodegradable polyester-based polymer, and as a result, the initial release of the drug molecule can be stopped by diffusion, so that a zero-order release rate can be obtained. . According to this technique, hydrophilic drug molecules can be filled into a preparation of microspheres, nanospheres, and films by a single oil-in-water emulsification method with high efficiency. After the target molecule is converted to the active form, it binds to the polymer, or the polymer is activated and binds to the target molecule. In both cases, due to coupling efficiency and high encapsulation efficiency of the drug molecule, the linkage between the drug molecule and the polymer includes a suitable spacer or a linker with / without a multifunctional group. |