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(57) [Summary]nA method for labeling β-amyloid plaques and neurofibrillary tangles in vivo and in vitro, comprising contacting a compound of formula (I) with mammalian tissue. In the formula (I), R 1 Is -C (O) -alkyl, -C (O) -alkylenyl-R Four , -C (O) O-alkyl, -C (O) O-alkylenyl-R Four , -C = C (CN) Two -Alkyl, -C = C (CN) Two -Alkylenyl-R Four , (A), (b) and (c); Four Is a group selected from the group consisting of alkyl, substituted alkyl, aryl and substituted aryl; Five Is -NH Two , -OH, -SH, -NH-alkyl, -NHR Four , -NH-alkylenyl-R Four , -O-alkyl, -O-alkylenyl-R Four , -S-alkyl, and -S-alkylenyl-R Four R is a group selected from the group consisting of: 6 Is -CN, -COOH, -C (O) O-alkyl, -C (O) O-alkylenyl-R Four , -C (O) -alkyl, -C (O) -alkylenyl-R Four , -C (O) -halogen, -C (O) NH Two , -C (O) NH-alkyl, and -C (O) NH-alkylenyl-R Four R is a group selected from the group consisting of: 7 Is a group selected from the group consisting of O, NH, and S; 8 Is N, O or S. R Two And R Three Are, independently of one another, alkyl and alkylenyl-R Ten Selected from the group consisting of Ten Is selected from the group consisting of -OH, -OTs, halogen, spiperone, spiperone ketal, and spiperon-3-yl. Alternatively, R Two And R Three Together form a heterocycle, which optionally comprises alkyl, alkoxy, OH, OTs, halogen, alkylenyl-R Ten , Carbonyl, spiperone, spiperone ketal and spiperon-3-yl. In the compounds of formula (I), one or more of said hydrogen, halogen or carbon atoms may be optionally replaced by a releasable label.nEmbedded image |