abstract |
(57) [Summary]nA compound of formula (I) or a pharmaceutically acceptable salt or solvate thereof, wherein: the dotted line represents any double bond; 1 Is optionally substituted alkyl, cycloalkyl, aryl, heteroaryl or heterocycloalkyl; X Two Is -CHO, -CN, optionally substituted amino, alkyl, or aryl; 1 Is an optionally substituted benzofused heterocycle, and X Two Is hydrogen; or X 1 And X Two Together form an optionally benzo-fused spiro heterocyclic group; 1 , R Two , R Three And R Four Are independently H and alkyl, or (R 1 And R Four ) Or (R Two And R Three ) Or (R 1 And R Three ) Or (R Two And R Four ) May together form an alkylene bridge of 1 to 3 carbon atoms; 1 Is an optionally substituted alkyl, aryl, heteroaryl, cycloalkyl or heterocycloalkyl, or -CO Two (Alkyl or substituted amino) or CN; Z Two Is H or Z 1 And Z Three Is H or alkyl; or Z 1 , Z Two And Z Three Together with the carbon to which they are attached form a bicyclic saturated or unsaturated ring; thus, pharmaceutical compositions and the treatment of the compounds for pain, anxiety, cough, asthma, depression and alcoholism Disclosed are the use as nociceptin receptor inhibitors useful for |