| abstract |
(57) [Summary] Compounds of formula (1), wherein R 1 , R 2 and R 3 are as defined in the above formula, are inhibitors of the enzyme protein tyrosine kinase, for example Janus Kinase 3, such as organ grafts Rejection, lupus, multiple sclerosis, rheumatoid arthritis, psoriasis, complications from type I diabetes and diabetes, cancer, asthma, atopic dermatitis, autoimmune thyroid disorders, ulcerative colitis, Crohn's disease, Alzheimer's disease, leukemia And useful as immunosuppressants for other autoimmune diseases. |