http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2002513021-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-496 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-12 |
| filingDate | 1999-04-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2002-05-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2002513021-A |
| titleOfInvention | Process for producing 1,3-disubstituted-4-oxocyclic ureas |
| abstract | (57) Abstract: A 1,3-disubstituted-4-oxo cyclic urea of the general formula (I) wherein R 1 , R 2 and R 3 are nil, Cl, F, Br, NH 2 , R 2 is independently selected from the group consisting of NO 2 , COOH, CH 3 SO 2 NH, SO 3 H, OH, alkoxy, alkyl, alkoxycarbonyl, hydroxyalkyl, carboxyalkyl, and acyloxy; A is selected from the group consisting of alkyl, alkenyl, alkynyl, alkylacyl and heteroalkyl, and A is a substituted or unsubstituted, saturated or unsaturated, linear or branched, composed of 1 to 7 carbon atoms. Is an alkyl or alkenylamino group, or A is a 5-, 6- or 7-membered substituted or unsubstituted, saturated or unsaturated heteroatom containing at least one nitrogen. In and, R 4 is attached to the nitrogen. Wherein the 1,3-disubstituted-4-oxocyclic urea is prepared without isolation of an intermediate, and Ia) in the presence of a mild base and a solvent. Reacting a 1-substituted-4-oxocyclic urea with a carbon chain containing at least two leaving groups to form an adduct containing at least one leaving group; and (Ib) adding the Condensing the product with an amine to form a 1,3-disubstituted-4-oxocyclic urea; and (II) recovering the 1,3-disubstituted-4-oxocyclic urea. Is disclosed. This method uses 1-[[[5- (4-chlorophenyl) -2-furanyl] methylene] amino] -3- [4- (4-methyl-1-piperazinyl) butyl] -2,4-imidazolidinedione. Particularly preferred for the production of Embedded image |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2002513022-A |
| priorityDate | 1998-04-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 73.