| abstract |
(57) Abstract: Formula containing at least one cyclic nitrogen (I): [wherein, X is a double bond oxygen, or -OH; if R 7 is present, it is hydrogen or lower alkyl ; y mono -, bi - or an tricyclic or heterocyclic ring, provided that each ring each have a 5-6 membered ring atoms; and Z is, (i) -CH 2 CHR 3 - Wherein R 2 and R 3 are independently hydrogen, alkyl, aryl or aralkyl; (ii) —R 6 C ＝ CR 3 — wherein R 3 and R 6 are independently hydrogen, lower alkyl, aryl, Aralkyl, halo, —NO 2 , —COOR 7 , or —NR 7 R 8 , wherein R 8 is independently hydrogen or C 1 -C 9 alkyl, or R 6 and R 3 together is to form a fused aromatic rings, each individual ring where having 5-6 membered ring; (iii) -R 2 C = N -; (iv) —CR 2 (OH) —NR 7 ; or (v) —C (O) —NR 7 ], or a pharmaceutically acceptable base or acid addition salt, hydrate, ester, solvate, pro Drugs, metabolites, stereoisomers or mixtures thereof, compositions containing compounds, methods of using compounds, and methods of making compounds. |