| abstract |
(57) [Summary]nEmbedded imagen A substituted heteroaromatic compound of the formula (I), and a salt or solvate thereof, wherein X is N or CH; 1 And V is N; or Y is N and V is CR 1 Or Y is CR 1 And V is CR 2 Or Y is CR 2 And V is CR 1 And R 1 Is CH 3 SO 2 CH 2 CH 2 NHCH 2 -Ar- groups wherein Ar is selected from phenyl, furan, thiophene, pyrrole and thiazole, each of which optionally contains one or two halo, C 1-4 Alkyl or C 1-4 Optionally substituted with an alkoxy group); 2 Is hydrogen, halo, hydroxy, C 1-4 Alkyl, C 1- 4 Alkoxy, C 1-4 Alkylamino and di [C 1-4 Alkyl] amino; U is R 3 At least one R substituted by a group and optionally further independently selected 4 Phenyl, pyridyl, 3 H -Imidazolyl, indolyl, isoindolyl, indolinyl, isoindolinyl, 1 H -Indazolyl, 2,3-dihydro-1 H -Indazolyl, 1 H -Benzimidazolyl, 2,3-dihydro-1 H -Benzimidazolyl or 1 H -A benzotriazolyl group; R 3 Is selected from the group consisting of benzyl, halo-, dihalo- and trihalobenzyl, benzoyl, pyridylmethyl, pyridylmethoxy, phenoxy, benzyloxy, halo-, dihalo- and trihalobenzyloxy and benzenesulfonyl; or R 3 Represents trihalomethylbenzyl or trihalomethylbenzyloxy; or R 3 Represents a group of the formula (a): 5 Is independently halogen, C 1-4 Alkyl and C 1-4 R is selected from alkoxy; and n is 0-3); 4 Is independently hydroxy, halogen, C 1-4 Alkyl, C 2-4 Alkenyl, C 2-4 Alkynyl, C 1-4 Alkoxy, amino, C 1-4 Alkylamino, di [C 1-4 Alkyl] amino, C 1-4 Alkylthio, C 1-4 Alkylsulfinyl, C 1-4 Alkylsulfonyl, C 1-4 Alkylcarbonyl, carboxy, carbamoyl, C 1-4 Alkoxycarbonyl, C 1-4 Alkanoylamino, N- (C 1-4 Alkyl) carbamoyl, N, N-di (C 1-4 Alkyl) carbamoyl, cyano, nitro and trifluoromethyl, and methods for their preparation, pharmaceutical compositions containing them and their use in medicine are disclosed. |