| abstract |
(57) [Problem] To provide a material for repairing a tissue defect capable of promptly treating a defect site in a tissue or an organ without repairing and healing a tissue defect portion without requiring extracellular cell culture. A tissue regeneration material in a body, comprising a cell adhesion active substance (A) and a bioabsorbable substance (B). In addition, (A) is synthesized by a genetically modified microorganism and has at least one (preferably 3 to 50) minimal amino acid sequence in a molecule that represents a cell adhesion signal. It is preferably a polypeptide (A1). In addition, the minimum amino acid sequence representing a cell adhesion signal is RG D sequence, LDV sequence, REDV sequence, YIGSR sequence, PDSGR sequence, RYVVLPR sequence, LGTIPG sequence, RNIAEIIKDI sequence, IKVAV sequence, LR It is preferably at least one kind of sequence selected from the group consisting of E sequence, DGEA sequence and HAV sequence. |