| abstract |
(57) [Summary] (with correction) [PROBLEMS] To provide a drug having a low anticoagulant activity and an excellent growth factor activity promoting effect. SOLUTION: The basic skeleton has a repeating structure of a disaccharide of hexosamine and hexuronic acid, and the constituent monosaccharide, hexuronic acid, is partially cleaved between carbon atoms at positions 2 and 3 and further cleaved. A glycosaminoglycan derivative (formula (1) below) in which part or all of the hydroxyl group at position 2 of hexuronic acid which has not been substituted with a sulfate group is used as a growth factor activity enhancer as an active ingredient. (However, R 1 is H or SO 3 H, and R 2 is COCH 3 or SO 3 H. ) |