| abstract |
(57) [Problem] To provide a preventive and / or therapeutic agent for a matrix metalloproteinase-related disease and a method for screening a substance that enhances the production of TIMP. SOLUTION: A preventive and / or therapeutic agent for a matrix metalloprotease-related disease containing a polysulfated polysaccharide as an active ingredient and a substance to be screened for synovial cells are added, and the production amount of a matrix metalloprotease inhibitor is measured. A method for screening a substance that enhances the production of a matrix metalloprotease inhibitor. |