| abstract |
(57) [Problem] To provide an excellent melanin-concentrating hormone antagonist. SOLUTION: The formula: [In the formula, Ar 1 and Ar 2 each represent an aromatic group which may have a substituent, and P and Q each represent a substituent which may contain ether oxygen or sulfur in the carbon chain. also be a divalent aliphatic hydrocarbon group, R 1 and R 3 is (i) hydrogen atom, a (ii) an acyl group or (iii) may be an optionally substituted hydrocarbon group, R 2 And R 4 each represent (i) a hydrogen atom, (ii) an alkyl group which may have a substituent or (i) ii) R 1 and R 2 or R 3 and R 4 represent an optionally substituted alkylcarbonyl, which may have a substituent together with an adjacent nitrogen atom. May form a ring group, and j represents 0 or 1] A melanin-concentrating hormone antagonist comprising a compound represented by the formula: or a salt thereof. |