| abstract |
(57) Abstract: The present invention provides a novel protein tyrosine phosphatase-modulating compound having a general structure represented by the formula (A1) YXC (R ') = C (R ") COOR'", and a method for preparing the same. The present invention relates to an in vitro system, a microorganism, a composition comprising said compound, its use for the treatment of human and animal disorders, and its use for the purification of proteins or glycoproteins, its use in diagnosis. R 'and R ", in eukaryotic cells, whole animals and humans, involving the activity of molecules with a phosphotyrosine recognition unit, including protein tyrosine phosphatase (PTPase) and proteins with a Src-homology-2 domain. Is independently selected from the group consisting of hydrogen, halo, cyano, nitro, trihalomethyl, alkyl, arylalkyl. R ′ ″ is selected from the group consisting of hydrogen, alkyl, substituted alkyl, aryl, arylalkyl. X is aryl. Y is selected from hydrogen or α, where ( * ) indicates a possible point of attachment to X. |