| abstract |
(57) [Problem] To provide a nucleic acid composition which can be expected to improve, prevent, or activate immune function of intestinal immune system by enhancing cytokine production in intestinal epithelium. SOLUTION: Oral ingestion of a nucleic acid composition shifts the expression ratio of γδ-IEL in the composition ratio of a subset of αβ-IEL and γδ-IEL in the IEL in a direction in which the expression ratio of γδ-IEL is increased. By Increased production of IFN-γ, IL-2, IL-7 and TGF-β in the small intestinal epithelium, and furthermore, oral ingestion of the nucleic acid composition induces production of antigen-specific secretory IgA antibody I found that. |