| abstract |
(57) Abstract: A process for preparing a compound having structure (I): wherein n is an integer from 1 to 5; and R 1 and R 2 are each independently an optionally substituted C 1 -C 6 alkyl. There; W and X is each independently hydrogen or C1-C6 alkyl; Y is O, S or NR 3, wherein R 3 is hydrogen, C1-C6 alkyl or a protecting group; and Z is A CD ring structure, a steroid structure or a vitamin D structure, each of which may optionally have one or more protected or unprotected substituents and / or one or more protecting groups. The method comprises reacting a compound having the structure (IV), wherein W, X, Y and Z are as defined above, in the presence of a base in the structure (V) or (V ′) (where n , R 1 and R 2 are as defined above, and E is a leaving group). |