http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2000510866-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-48 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 |
| filingDate | 1997-05-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2000-08-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2000510866-A |
| titleOfInvention | Quinoline sulfonamides as inhibitors of TNF and PDE-IV |
| abstract | (57) [Summary] A compound represented by the following general formula (i): Wherein R represents H, a halogen atom or alkyl; R 1 represents alkoxy, OH or thioalkyl optionally substituted by one or more halogen atoms; R 2 , R 3 and R 4 It may be the same or different, each H, R 7, oR 11, COR 7, C (= NOR 7) R 7, alkyl -C (= NOR 7) R 7 , alkyl -C (= NOH) R 7 , C (= NOH) R 7 , halogen atom, CF 3 , CN, CO 2 H) CO 2 R 11 , CONH 2 , CONHR 7 , CON (R 7 ) 2 , NR 9 R 10 or CONR 12 R 13 (formula Wherein NR 12 R 13 represents a heterocyclo ring optionally substituted by one or more R 15 ), and R 5 represents H, arylalkyl, heteroarylalkyl, S (O) mR 11 Or alkyl (The group is selected from the group consisting of hydroxy, alkoxy, CO 2 R 8 , SO 2 NR 12 R 13 , CONR 12 R 13 , CN, carbonyl oxygen, NR 9 R 10 , COR 11 and S (O) nR 11. Optionally substituted by one or more groups), and R 6 represents aryl, heteroaryl, arylalkyl or heteroarylalkyl. The compounds can be used to treat disease states, such as those associated with proteins that mediate cellular activity, for example, by inhibiting tumor necrosis factor and / or phosphodiesterase IV. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2007501264-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2012532137-A |
| priorityDate | 1996-05-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 180.