| abstract |
PROBLEM TO BE SOLVED: To provide a neurokinin 1 receptor antagonist, comprising: pain, headache, Alzheimer's disease, multiple sclerosis, alleviation of morphine withdrawal, cardiovascular changes, edema, chronic inflammatory disease, respiratory organs The present invention provides a medicament effective for diseases, intestinal inflammatory diseases, eye damage, and eye inflammatory diseases. SOLUTION: Formula (I): (Wherein R is hydrogen and the like; R 1 is hydrogen and the like; R 2 and R 2 'as hydrogen; R 3 is hydrogen, etc.; R 4 is hydrogen, and the like; R 5 is hydrogen or the like; R 6 is hydrogen or the like; X is —C (O) N (R 5) -, such as; n is an integer of 0 to 4; is m, 1 or 2 ), A medicament containing the compound, and a method for producing the same. |