http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-831897-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_97a285d8ecd0184a7e5d89a1e4e07997 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-2027 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K33-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K33-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-20 |
| filingDate | 1957-07-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b373bae6e0db5502f9c0fcac4326699a |
| publicationDate | 1960-04-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-831897-A |
| titleOfInvention | Antacid preparation and process for making same |
| abstract | An antacid preparation comprises a non-toxic antacid substance which is an oxide, hydroxide, carbonate or hydroxy salt of magnesium together with a non-toxic water-soluble synthetic polymer which is a polymer of acrylic acid cross-linked with a polyhydroxy compound having at least 3 hydroxy groups, such as a polyhydroxy alcohol, wherein the hydrogen atoms of at least three hydroxyl groups are replaced with unsaturated aliphatic radicals, preferably having 2-4 carbon atoms, or cross-linked with an unsaturated ether or unsaturated saccharide ether or unsaturated ester having at least three double bonds available for cross-linking such as the tri-acrylic acid ester of glycerol and acrylic acid esters of glycerol having from 3-8 acid residues. The polyhydroxy compounds specified are glucose, fructose, mannose, galactose, sucrose, lactose, maltose, glycerol, erythritol, dulcitol, mannitol, sorbitol, pentaerythritol. The preferred cross-linkers are polyallyl sucrose and polyallyl pentaerythritol, preferably present from 0.75 to 1.5% by weight with respect to the polymer. The cross-linked polymer may be subjected to the action of steam to form a porous cake, the cake being dried and milled to a predetermined size. The antacid and polymer are preferably present in the ratio by weight of 1 part of polymer to 1-6 parts of antacid. For tabletting binders such as gelatin, gum acacia, tragacanth, pectin and diluents such as starch, talc and terra alba may be used.ALSO:An antacid preparation comprises a non-toxic antacid substance p which is an oxide, hydroxide, carbonate or hydroxy salt of magnesium together with a non-toxic water-soluble synthetic polymer which in aqueous solution forms a gel at a pH above 4.5 but which remains fluid at a lower pH. The polymer used should preferably buffer the antacid to lower the pH and increase in viscosity after passing into the duodenum to provide a bulking action. Specified is a polymer of acrylic acid cross-linked with a polyhydroxy compound having at least 3 hydroxy groups, such as a polyhydroxy alcohol, wherein the hydrogen atoms of at least three hydroxyl groups are replaced with unsaturated aliphatic radicals preferably having 2-4 carbon atoms, or cross-linked with an unsaturated ether or unsaturated saccharide ether or unsaturated ester having at least three double bonds available for cross-linking, such as the tri-acrylic acid ester of glycerol and acrylic acid esters of glycerol having from 3-8 acid residues. The polyhydroxy compounds specified are glucose, fructose, mannose, galactose, sucrose, lactose, maltose, glycerol, erythritol, dulcitol, mannitol, sorbitol pentaerythritol. The preferred cross-linkers are polyallyl sucrose and polyallyl pentaerythritol, preferably present from 0.75% to 1.5% by weight with respect to the polymer. The cross-linked polymer may be subjected to the action of steam to form a porous cake, the cake being dried and milled to a predetermined size. The antacid and polymer are preferably present in the ratio by weight of 1 part of polymer to 1-6 parts of antacid. For tabletting binders such as gelatin, gum acacia, tragacanth, pectin and diluents such as starch, talc and terra alba may be used. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2018204317-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110709068-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110709068-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110780063-A |
| priorityDate | 1957-07-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 76.