| abstract |
The techniques disclosed herein provide improved pharmaceutical compositions and methods for their preparation that provide increased stability, higher drug loading, and suitable drug dissolution properties. The composition comprises: (a) a drug component comprising a therapeutically effective amount of a drug; (b) a sustained-release component comprising a cross-linked polyacrylic acid polymer, the cross-linked polyacrylic acid polymer is a carbomer homopolymer, a carbomer Bohm copolymer, carbomer interpolymer, polycarbophil, or mixtures thereof; and (c) a buffer component comprising a magnesium-containing buffer; wherein the pharmaceutical component comprises at least 50% by weight of the composition. |