http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-825562-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c902faf6ae746c51fc8010672fc22894 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-10 |
| filingDate | 1956-07-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1959-12-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-825562-A |
| titleOfInvention | Substituted spiro-pyrrolidines |
| abstract | The invention comprises compounds of the general formula <FORM:0825562/IV (b)/1> wherein m is one or two, R1 is hydrogen or methyl and R11 is hydrogen or a methyl or an oxo group and the preparation thereof by condensing a nitrocycloalkane of the general formula <FORM:0825562/IV (b)/2> with a compound of the general formula <FORM:0825562/IV (b)/3> wherein R is a methyl or a lower alkoxy group (one to eight carbon atoms), to form a compound of the general formula <FORM:0825562/IV (b)/4> and reductively cyclizing the formed compound to give a spiro-pyrrolidine of the invention. In examples, nitro-cyclohexane is condensed with methyl acrylate in the presence of benzyl-trimethylammonium hydroxide to yield methyl b - (1 - nitrocyclohexyl)-propionate which is hydrogenated in the presence of Raney nickel catalyst to give spiro-[cyclohexane-1,21-pyrroli-done-51], and which in turn is reduced by lithium aluminium hydride to form spiro-[cyclo-hexane-1,21-pyrrolidine]. Similarly is prepared methyl b - (1 - nitrocyclopentyl) - propionate, spiro - [cyclopentane - 1,21 - pyrrolidone - 51] and spiro - [cyclopentane - 1,21 - pyrrolidine], the reduction to the pyrrilidone being carried out by hydrogenation under pressure in the presence of Raney nickel catalyst. Specification 825,561 is referred to. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0414274-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0414274-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5091567-A |
| priorityDate | 1955-07-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 27.