| abstract |
The invention relates to a novel embodiment of the Michael addition in the production of 1-aminomethyl-1-cyclohexane acetic acid (gabapentin), starting from cyclohexanone. By using KOH in the first reaction step, reaction with nitromethane in DMSO with catalysis of an alkali metal carbonate and reduction of the introduced nitro group at elevated temperature, the yield is increased and the safety of the production process is significantly increased. |