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filingDate 1971-11-19-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 1974-03-27-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber GB-1349158-A
titleOfInvention Pharmaceutical compositions
abstract 1349158 Corticosteroid preparations ETABS ARPIC SA 17 Nov 1972 [19 Nov 1971] 53945/ 71 Heading A5B Pharmaceutical compositions suitable for topical, oral and rectal administration comprise carrier particles coated with a corticosteroid. The carrier may be talc, colloidal SiO 2 , Al 2 O 3 , bentonite, kaolin, magnesium trisilicate, lactose corn starch, microspheres of a synthetic polymer, a metal stearate, cellulose, a cellulose derivative, ZnO, TiO 2 or a pharmacologically active ingredient, e.g. bismuth oxyiodide, oxychloride, subnitrate, subcarbonate or subgallate, a sulphonamide, neomycin sulphate, tetracycline hydrochloride, chloramphenicol, amphoteracin B or nistatine. The steroid may be prednacinolone, triamcinolone acetonide, fluocinolone acetonide, flumethasone pivalate, hydrocortisone acetate, triamcinolone, prednisolone, pregnenolone or betamethasone. The coated particles may also include a surface active agent, e.g. glycerol monostearate or palmitate or ethylene oxide adducts of lauryl, cetyl, stearyl or oleyl alcohol, stearic acid, sorbitan stearate, laurate, palmitate or oleate, glycerol stearate laurate, palmitate or oleate or lanolin. They may be prepared by dissolving the corticosteroid in an organic solvent or an organic solvent / water emulsion, suspending the carrier in this solution and spray drying the product. The coated particles may be mixed with other ingredients e.g. other active ingredients such as lidocaine hydrochloride, a tabletting lubricant, e.g. magnesium stearate and other carrier and excipients. The product may be put up as powder, tablets, gelatin capsules or suppositories, which may be used in treating haemorrhoids.
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