| abstract |
1,201,997. Purines and purine derivatives. YISSUM RESEARCH DEVELOPMENT CO. OF THE HEBREW UNIVERSITY OF JERUSALEM. 25 July, 1968 [4 Aug., 1967], No. 35513/68. Heading C2C. Novel 8-pyridyl- and 8-N-methylpyridiniumsubstituted purines and purine derivatives are prepared by direct condensation of the appropriate 4,5-diaminopyrimidines with an amidine. In forming the 6-mercaptopurine compounds it is preferred to sulphurate the corresponding hypoxanthine. 1 - Methyl - 3 - amidinopyridinium iodide hydriodide is prepared by keeping a solution of 3-amidinopyridine hydrochloride in dimethylformamide and methyl iodide at room temperature for 24 hours. 6-mercapto-8-phenylpurine is prepared by refluxing a mixture of 8-phenylhypoxanthine, phosphorus pentasulphide and dry pyridine 8-phenyl-6-thioxan. thine is prepared by sulphurating 8-phenylxanthine as described above. Pharmaceutical compositions comprising of 8 - pyridyl - and 8 - N - methyl-pyridinium-substituted purines and purine derivatives and having anti-tumor and hypotensive activity. Reference is made to Specifications 1,073,039, 1,073,040 and 1,077,689. |