http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1143167-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3c82fea9cd3dc48540ebd26d3b952479 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-505 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-505 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-42 |
| filingDate | 1967-01-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8b2bc953cab123d35e4208f6a1e7d66e |
| publicationDate | 1969-02-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1143167-A |
| titleOfInvention | Derivatives of pyrimidine |
| abstract | 1,143,167. Pyrimidine derivatives. UCB (UNION CHIMIQUE-CHEMISCHE BEDRIJVEN) S.A. 24 Jan., 1968 [25 Jan., 1967], No. 3774/67. Heading C2C. Novel pyrimidine derivatives of formula in which R 1 is a hydrogen atom or a C 1-5 alkyl group, R 2 is a hydrogen or halogen atom or a C 1-5 alkyl, hydroxyalkylamino, #-aryl- #-hydroxyalkylamino or morpholino group, R 3 is a hydrogen atom, a C 1-5 alkyl group which may be substituted by one or more hydroxy groups, or an aralkyl group, R 4 is a C 2-5 alkyl group which is substituted by one or more hydroxy groups, each hydroxy group being separated from the nitrogen atom to which the alkyl group is attached by at least two carbon atoms, or R 3 and R 4 , together with the nitrogen atom to which they are attached, represent a morpholino group, and their acid addition salts, are prepared (a) when R 2 is a hydrogen atom or an alkyl radical, by reacting a 2-R 1 -6-halo-pyrimi. dine or 2 - R 1 - 4 - alkyl - 6 - halo - pyrimidine with a primary or secondary hydroxylamine or with morpholine, or (b) when R 2 is a halogen atom or a hydroxyalkylamino or morpholino group, by reacting a 2-R1-4,6-dihalo-pyrimidine with a primary or secondary hydroxyalkylamine or with morpholine under such conditions and in such an amount that a 2-R 1 -4-halo-6- hydroxyalkylamino - pyrimidine, 2 - R 1 - 4 - halo - 6 - morpholino - pyrimidine, 2 - R 1 - 4,6- bis - hydroxyalkylamino - pyrimidine or 2-R 1 - 4,6 - dimorpholino - pyrimidine is obtained, or (c), when R 2 is a hydroxyalkylamino, #-aryl-#- hydroxyalkylamino or morpholino group, by reacting a 2-R 1 -4-halo-6-hydroxyalkylaminopyrimidine or 2-R 1 -4-halo-6-morpholino-pyrimidine with a primary hydroxyalkylamine or #- aryl-#-hydroxyalkylamine or morpholine and, if desired, converting a resulting base into an acid addition salt. Pharmaceutical compositions having hypotensive, vasodilatory, diuretic, bronchodilatory, spasmolytic and analeptic properties, comprise one of the novel compounds together with a carrier. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5438058-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2006044732-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0806418-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2008516974-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2011105572-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8193183-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2005520821-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7517889-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/FR-2662607-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-101039920-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-03087064-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/NO-339772-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6080750-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0459890-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0806418-A2 |
| priorityDate | 1967-01-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 41.