| abstract |
The present invention relates to the field of biology, genetics and medicine. It concerns in particular new methods for the detection, characterization and / or treatment (or management) of neurodegenerative pathologies. The invention also relates to methods for the identification or screening of active compounds in these pathologies. The invention also relates to compounds, genes, cells, plasmids or compositions useful for the implementation of the methods above. The invention derives in particular from the identification of the role of phosphodiesterase 4B and the peripheral benzodiazepine receptor in degenerative pathologies and describes their use as a target or a therapeutic, diagnostic or experimental marker for these disorders. |