| abstract |
The aim of the invention is to provide a multi (micro) particulate tablet, comprising a core of mechanically non-deformable PA active principle (crystal, granule), allowing the sustained release in vivo of this PA, without modification of the release profile by compression (microparticles not specifically formulated for compression). This object is achieved by the tablet according to the invention, based on reservoir microcapsules, with prolonged release of the AP, and :. each formed by a non-deformable core comprising the AP and covered by at least one coating film controlling the sustained release in vivo of the AP ,. having a particle size of between 50 and 1000 m. and comprise at least one outer overcoat envelope based on at least one deformable organic constituent having a melting point of between 40 ° C and 120 ° C (polyethylene glycol). such by the invention. |